Gene name:
Enpp2 (Npps2;Pdnp2) ;
Protein name:
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (E-NPP 2) ;
Alternative:
Extracellular lysophospholipase D (LysoPLD) ;Autotaxin ;
Organism:
Mouse (Mus musculus).
General Annotation
Function:
Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor.
Subcellular Location:
Secreted
Secreted by most body fluids including serum and CSF. Also by adipocytes and numerous cancer cells.
Protein Attributes:
50:
MARQGCFGSY | QVISLFTFAI | GVNLCLGFTA | SRIKRAEWDE | GPPTVLSDSP |
100:
WTNTSGSCKG | RCFELQEVGP | PDCRCDNLCK | SYSSCCHDFD | ELCLKTARGW |
150:
ECTKDRCGEV | RNEENACHCS | EDCLSRGDCC | TNYQVVCKGE | SHWVDDDCEE |
200:
IRVPECPAGF | VRPPLIIFSV | DGFRASYMKK | GSKVMPNIEK | LRSCGTHAPY |
250:
MRPVYPTKTF | PNLYTLATGL | YPESHGIVGN | SMYDPVFDAT | FHLRGREKFN |
300:
HRWWGGQPLW | ITATKQGVRA | GTFFWSVSIP | HERRILTILQ | WLSLPDNERP |
350:
SVYAFYSEQP | DFSGHKYGPF | GPEMTNPLRE | IDKTVGQLMD | GLKQLKLHRC |
400:
VNVIFVGDHG | MEDVTCDRTE | FLSNYLTNVD | DITLVPGTLG | RIRPKIPNNL |
450:
KYDPKAIIAN | LTCKKPDQHF | KPYMKQHLPK | RLHYANNRRI | EDLHLLVERR |
500:
WHVARKPLDV | YKKPSGKCFF | QGDHGFDNKV | NSMQTVFVGY | GPTFKYRTKV |
550:
PPFENIELYN | VMCDLLGLKP | APNNGTHGSL | NHLLRTNTFR | PTLPEEVSRP |
600:
NYPGIMYLQS | DFDLGCTCDD | KVEPKNKLEE | LNKRLHTKGS | TEERHLLYGR |
650:
PAVLYRTSYD | ILYHTDFESG | YSEIFLMPLW | TSYTISKQAE | VSSIPEHLTN |
700:
CVRPDVRVSP | GFSQNCLAYK | NDKQMSYGFL | FPPYLSSSPE | AKYDAFLVTN |
750:
MVPMYPAFKR | VWTYFQRVLV | KKYASERNGV | NVISGPIFDY | NYNGLRDIED |
800:
EIKQYVEGSS | IPVPTHYYSI | ITSCLDFTQP | ADKCDGPLSV | SSFILPHRPD |
850:
NDESCNSSED | ESKWVEELMK | MHTARVRDIE | HLTGLDFYRK | TSRSYSEILT |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Bovine
Rat
ELISA Kit for Mouse E-NPP 2
ELISA Kit for Mouse E-NPP 2
ELISA Kit for Mouse E-NPP 2
ELISA Kit for Mouse E-NPP 2
CLIA Kit for Mouse E-NPP 2
CLIA Kit for Mouse E-NPP 2
CLIA Kit for Mouse E-NPP 2
CLIA Kit for Mouse E-NPP 2
Polyclonal Antibody for Mouse E-NPP 2
Polyclonal Antibody for Mouse E-NPP 2
Polyclonal Antibody for Mouse E-NPP 2
Polyclonal Antibody for Mouse E-NPP 2
Monoclonal Antibody for Mouse E-NPP 2
Monoclonal Antibody for Mouse E-NPP 2
Monoclonal Antibody for Mouse E-NPP 2
Monoclonal Antibody for Mouse E-NPP 2
Protein for Mouse E-NPP 2
Protein for Mouse E-NPP 2
Protein for Mouse E-NPP 2
Protein for Mouse E-NPP 2
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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C57BL/6 .
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Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3);ENZYME REGULATION;BIOPHYSICOCHEMICAL PROPERTIES;TISSUE SPECIFICITY
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Science309:1559-1563(2005)
[
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[
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
strain :
C57BL/6J .
tissue :
Skin .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
strain :
C57BL/6 .
strain :
FVB/N .
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Mammary gland .
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Retina .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INDUCTION;POSSIBLE FUNCTION IN OBESITY
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEOLYTIC CLEAVAGE;SUBCELLULAR LOCATION;FUNCTION;GLYCOSYLATION;MUTAGENESIS OF 12-VAL--VAL-22; 12-VAL--GLY-27; 23-ASN--GLY-27; CYS-25; GLY-27; 27-GLY--ALA-30; 27-GLY--ARG-35; 30-ALA--ILE-33; 30-ALA--GLY-41; 32-ARG--ARG-35; 36-ALA--GLU-40; ASN-53 AND ASN-410
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERDOMAIN DISULFIDE BOND;MUTAGENESIS OF 851-LEU--THR-853; LEU-851; LYS-852 AND THR-853
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 36-862 IN COMPLEXES WITH LYSOPHOSPHATIDIC ACID; ZINC AND CALCIUM IONS;FUNCTION;CATALYTIC ACTIVITY;COFACTOR;DISULFIDE BONDS;GLYCOSYLATION AT ASN-53; ASN-410 AND ASN-524;SUBCELLULAR LOCATION;MUTAGENESIS OF PHE-210; LEU-213; ASN-230; LEU-243; GLU-247 AND PHE-249
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS) OF 51-58
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 36-862 IN COMPLEXES WITH INHIBITORS AND ZINC;GLYCOSYLATION AT ASN-53; ASN-410 AND ASN-524;CATALYTIC ACTIVITY;COFACTOR;DISULFIDE BOND